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Issue 12, 2016
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2D wax-printed paper substrates with extended solvent supply capabilities allow enhanced ion signal in paper spray ionization

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Abstract

Paper-based microfluidic channels were created from solid wax printing, and the resultant 2D wax-printed paper substrates were used for paper spray (PS) mass spectrometry (MS) analysis of small organic compounds. Controlling fluid flow at the tip of the wax-printed paper triangles enabled the use of lower spray voltages (0.5–1 kV) and extended signal lifetime (10 minutes) in PS-MS. High sensitivity (sub ng mL−1 levels) and quantitation precision (<10% RSD) have been achieved in the analysis of illicit drugs in 4 μL of raw urine (fresh and dry), as well as corrosion inhibitors and pesticides in water samples. The reported study encourages the future development of disposable 3D microfluidic paper-based analytical devices, which function with simple operation but capable of on-chip analyte detection by MS; such a device can replace the traditional complex laboratory procedures for MS analysis to enable on-site in situ sampling with portable mass spectrometers.

Graphical abstract: 2D wax-printed paper substrates with extended solvent supply capabilities allow enhanced ion signal in paper spray ionization

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Supplementary files

Article information


Submitted
23 Jan 2016
Accepted
15 Apr 2016
First published
18 Apr 2016

Analyst, 2016,141, 3866-3873
Article type
Paper

2D wax-printed paper substrates with extended solvent supply capabilities allow enhanced ion signal in paper spray ionization

D. E. Damon, Y. S. Maher, M. Yin, F. P. M. Jjunju, I. S. Young, S. Taylor, S. Maher and A. K. Badu-Tawiah, Analyst, 2016, 141, 3866
DOI: 10.1039/C6AN00168H

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