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Issue 12, 2016
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Factors influencing polyelectrolyte-aptamer multilayered films with target-controlled permeability for sensing applications

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Abstract

Portable, easy-to-use and cost-effective sensing devices are desirable in healthcare, environmental monitoring and food safety. Herein we employ polyelectrolyte-aptamer (PE-aptamer) multilayered films that exhibit target-responsive permeability for colorimetric and electrochemical sensing. We present the quantitative detection of an exemplary small molecule, quinine, and address the potential for detection in complex media by examining interference effects. We optimize the film composition and investigate the importance of the structural-switching ability of the aptamer. The results from both platforms are corroborated to provide an outlook on the applicability of the PE-aptamer film for sensing. The label-free detection combined with the readily adaptive assembly process could be invaluable for diverse analytical fields.

Graphical abstract: Factors influencing polyelectrolyte-aptamer multilayered films with target-controlled permeability for sensing applications

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Supplementary files

Article information


Submitted
23 Oct 2015
Accepted
14 Dec 2015
First published
15 Dec 2015

Analyst, 2016,141, 3794-3802
Article type
Paper
Author version available

Factors influencing polyelectrolyte-aptamer multilayered films with target-controlled permeability for sensing applications

B. Malile and J. I. L. Chen, Analyst, 2016, 141, 3794
DOI: 10.1039/C5AN02198G

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