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Issue 12, 2016
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Ion collision cross section measurements in Fourier transform-based mass analyzers

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Abstract

With the increasing demands of molecular structure analysis, several methods have been developed to measure ion collision cross sections within Fourier transform (FT) based mass analyzers. Particularly in the recent three years since 2012, the method of obtaining biomolecule collision cross sections was achieved in Fourier transform ion cyclotron resonance (FT-ICR) cells. Furthermore, similar methods have been realized or proposed for orbitraps and quadrupole ion traps. This technique adds a new ion structure analysis capability to FT-based mass analyzers. By providing complementary ion structure information, it could be used together with tandem mass spectrometry and ion mobility spectroscopy techniques. Although many questions and challenges remain, this technique potentially would greatly enhance the ion structure analysis capability of a mass spectrometer, and provide a new tool for chemists and biochemists.

Graphical abstract: Ion collision cross section measurements in Fourier transform-based mass analyzers

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Article information


Submitted
20 Oct 2015
Accepted
04 Jan 2016
First published
05 Jan 2016

Analyst, 2016,141, 3554-3561
Article type
Minireview

Ion collision cross section measurements in Fourier transform-based mass analyzers

D. Li, Y. Tang and W. Xu, Analyst, 2016, 141, 3554
DOI: 10.1039/C5AN02164B

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