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Issue 12, 2016
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A membrane-activatable near-infrared fluorescent probe with ultra-photostability for mitochondrial membrane potentials

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Abstract

Mitochondrial membrane potential (MMP) is a frequently used indicator for mitochondrial function. Herein, we report a photostable near-infrared (NIR) fluorescent dye for monitoring MMP. This new probe, named NIMAP, is non-fluorescent in aqueous solution and can be activated by cell membranes, providing high fluorescence contrast and low background fluorescence. NIMAP has been validated for monitoring MMP in living mammalian cells and in mice. Due to the large fluorescence response, low fluorescence background, high photostability, and excellent tissue penetration resulting from red-shifted excitation and emission in the “optical window” above 600 nm, broad applications of this new probe are expected.

Graphical abstract: A membrane-activatable near-infrared fluorescent probe with ultra-photostability for mitochondrial membrane potentials

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Supplementary files

Article information


Submitted
09 Sep 2015
Accepted
28 Oct 2015
First published
28 Oct 2015

Analyst, 2016,141, 3679-3685
Article type
Paper
Author version available

A membrane-activatable near-infrared fluorescent probe with ultra-photostability for mitochondrial membrane potentials

W. Ren, A. Ji, O. Karmach, D. G. Carter, M. M. Martins-Green and H. Ai, Analyst, 2016, 141, 3679
DOI: 10.1039/C5AN01860A

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