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Issue 14, 2016
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Temperature-dependent shape-responsive fluorescent nanospheres for image-guided drug delivery

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Abstract

Temperature-responsive nanoparticles used in conjunction with hyperthermia promise to provide synergistic effects for increasing drug efficacy. We propose a near-infrared (NIR) fluorescent system based on a upper critical solution temperature (UCST) polymer, ISP2, integrated with a NIR fluorescent dye HITC for in vivo tracking. The system forms a nanoparticle that increases its volume as temperature increases, similar to the expansion of a Hoberman sphere. The nanospheres nearly doubled in size, from 80 nm to 140 nm, during a temperature increase from 40 °C to 65 °C.

Graphical abstract: Temperature-dependent shape-responsive fluorescent nanospheres for image-guided drug delivery

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Article information


Submitted
11 Jan 2016
Accepted
18 Feb 2016
First published
19 Feb 2016

J. Mater. Chem. C, 2016,4, 3028-3035
Article type
Paper
Author version available

Temperature-dependent shape-responsive fluorescent nanospheres for image-guided drug delivery

S. He, G. Tourkakis, O. Berezin, N. Gerasimchuk, H. Zhang, H. Zhou, A. Izraely, W. J. Akers and M. Y. Berezin, J. Mater. Chem. C, 2016, 4, 3028
DOI: 10.1039/C6TC00122J

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