Jump to main content
Jump to site search

Issue 36, 2016
Previous Article Next Article

Ductile silica/methacrylate hybrids for bone regeneration

Author affiliations


Bioglass® was the first synthetic material capable of bonding with bone without fibrous encapsulation, and fulfils some of the criteria of an ideal synthetic bone graft. However, it is brittle and toughness is required. Here, we investigated hybrids consisting of co-networks of high cross-linking density polymethacrylate and silica (class II hybrid) as a potential new generation of scaffold materials. Poly(3-(methoxysilyl)propyl methacrylate) (pTMSPMA) and tetraethyl orthosilicate (TEOS) were used as sol–gel precursors and hybrids were synthesised with different inorganic to organic ratios (Ih). The hybrids were nanoporous, with a modal pore diameter of 1 nm. At Ih = 50%, the release of silica was controlled by varying the molecular weight of pTMSPMA while retaining a specific surface area above 100 m2 g−1. Strain to failure increased to 14.2%, for Ih = 50% using a polymer of 30 kDa, compared to 4.5% for pure glass. The modulus of toughness (UT) increased from 0.73 (pure glass) to 2.64 GPa. Although, the hybrid synthesised in this report did not contain calcium, pTMSPMA/SiO2 hybrid was found to nucleate bone-like mineral on its surface after 1 week of immersion in simulated body fluid (SBF), whereas pure silica sol–gel glass did not. This increase in apatite forming ability was due to the ion–dipole complexation of calcium with the ester moieties of the polymer that were exposed after release of soluble silica from TEOS. No adverse cytotoxicity for MC3T3-E1 osteoblast-like cells was detected and improved cell attachment was observed, compared to a pure silica gel. pTMSPMA/SiO2 hybrids have potential for the regeneration of hard tissue as they overcome the major drawbacks of pure inorganic substrates while retaining cell attachment.

Graphical abstract: Ductile silica/methacrylate hybrids for bone regeneration

Back to tab navigation

Publication details

The article was received on 19 Apr 2016, accepted on 12 Aug 2016 and first published on 16 Aug 2016

Article type: Paper
DOI: 10.1039/C6TB00968A
J. Mater. Chem. B, 2016,4, 6032-6042

  •   Request permissions

    Ductile silica/methacrylate hybrids for bone regeneration

    A. L. B. Maçon, S. Li, J. J. Chung, A. Nommeots-Nomm, A. K. Solanki, M. M. Stevens and J. R. Jones, J. Mater. Chem. B, 2016, 4, 6032
    DOI: 10.1039/C6TB00968A

Search articles by author