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Issue 1, 2016
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Nd3+-doped LiYF4 nanocrystals for bio-imaging in the second near-infrared window

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Abstract

The fluorescent probes working in the near-infrared (NIR) window have unparalleled advantages of a high penetration depth and low interference from autofluorescence. In this paper we introduced a rare-earth doped nanoprobe working in this region with a narrow emission band, a high efficiency, and good bio-compatibility. The newly-developed host material LiYF4 managed to strengthen the emission intensity and generate a fine structure of the emission peaks. After the optimization of the doping ratio of Nd3+ and surface modification, the LiYF4:5%Nd3+ probe could reach a penetration depth of 3–5 mm and could be successfully utilized in lymphatic imaging, with a signal-to-noise ratio of 14.8 in vivo and a resolution of ∼0.2 mm in circulatory imaging. This probe may be further used in bio-detection and the host material itself may replace the traditional NaYF4 in some aspects of applications.

Graphical abstract: Nd3+-doped LiYF4 nanocrystals for bio-imaging in the second near-infrared window

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Supplementary files

Article information


Submitted
29 Sep 2015
Accepted
16 Nov 2015
First published
16 Nov 2015

J. Mater. Chem. B, 2016,4, 87-95
Article type
Paper
Author version available

Nd3+-doped LiYF4 nanocrystals for bio-imaging in the second near-infrared window

X. Jiang, C. Cao, W. Feng and F. Li, J. Mater. Chem. B, 2016, 4, 87
DOI: 10.1039/C5TB02023A

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