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Issue 9, 2016
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Self-assembled hybrid supraparticles that proteolytically degrade tumor necrosis factor-α

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Abstract

The strategies of pathogens to evade the human immune system are highly sophisticated and modulate a variety of inflammatory pathways. The similarities in the demands for modulation of inflammatory responses during disease treatment and during pathogenic infection provide opportunities to use pathogenic virulence factors to develop a new class of therapeutic materials that control inflammation. In this work, we harness a strategy from Porphyromonas gingivalis by transforming its major virulence factor, an arginine-specific cysteine protease, into self-assembled protease-inorganic hybrid supraparticles. The cysteine protease degrades the pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-α). It is an irreversible inhibition of TNF-α, which avoids some of the adverse effects of current TNF-α antagonists. We fabricated self-assembled porous supraparticles that specifically incorporate the pathogen-derived protease and showed improved inactivation of TNF-α over soluble enzyme, creating a potential therapeutic for various autoimmune diseases or other sources of inflammation.

Graphical abstract: Self-assembled hybrid supraparticles that proteolytically degrade tumor necrosis factor-α

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Supplementary files

Article information


Submitted
13 Aug 2015
Accepted
27 Oct 2015
First published
02 Nov 2015

J. Mater. Chem. B, 2016,4, 1633-1639
Article type
Paper

Self-assembled hybrid supraparticles that proteolytically degrade tumor necrosis factor-α

W. M. Park, C. M. Yee and J. A. Champion, J. Mater. Chem. B, 2016, 4, 1633
DOI: 10.1039/C5TB01647A

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