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Issue 4, 2016
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Monolith-based 68Ga processing: a new strategy for purification to facilitate direct radiolabelling methods

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Abstract

The post-processing of 68Ga generator eluate by means of a novel high capacity cation-exchange silica monolith column has been validated in this work. Quantitative release of a purified 68Ga solution in high concentration can be achieved using weak acidic solutions which can be directly used for chelator or conjugate labelling in an injectable form with improved radiochemical characteristics. The system has the potential to be incorporated in a flow based microfluidic system for dose-on-demand radiotracer synthesis.

Graphical abstract: Monolith-based 68Ga processing: a new strategy for purification to facilitate direct radiolabelling methods

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Supplementary files

Article information


Submitted
12 Apr 2016
Accepted
09 Jun 2016
First published
29 Jun 2016

This article is Open Access

React. Chem. Eng., 2016,1, 361-365
Article type
Communication
Author version available

Monolith-based 68Ga processing: a new strategy for purification to facilitate direct radiolabelling methods

P. He, B. P. Burke, G. S. Clemente, N. Brown, N. Pamme and S. J. Archibald, React. Chem. Eng., 2016, 1, 361
DOI: 10.1039/C6RE00081A

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