Issue 3, 2016

Controlled generation and use of CO in flow

Abstract

A method for the generation and use of carbon monoxide in flow chemistry has been developed. By using a tube-in-tube reactor, oxalyl chloride can be conveniently and safely hydrolyzed using a NaOH solution to generate CO in the outer stream, which then passes through AF-2400 semi-permeable inner tubing to enrich a reaction stream where it is consumed. The tube-in-tube reactor allows the generation of CO under conditions which would otherwise be incompatible with the reaction conditions. In this way carbonylations can be successfully performed in flow without the use of pressurized gas cylinders. Both alkoxy- and aminocarbonylation was carried out in flow, including a 320 minute continuous run, as proof of concept.

Graphical abstract: Controlled generation and use of CO in flow

Associated articles

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Article information

Article type
Paper
Submitted
29 Jan 2016
Accepted
18 Feb 2016
First published
25 Feb 2016
This article is Open Access
Creative Commons BY license

React. Chem. Eng., 2016,1, 280-287

Author version available

Controlled generation and use of CO in flow

S. V. F. Hansen, Z. E. Wilson, T. Ulven and S. V. Ley, React. Chem. Eng., 2016, 1, 280 DOI: 10.1039/C6RE00020G

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