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Issue 57, 2016
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Coordination chemistry of pyrazine derivatives analogues of PZA: design, synthesis, characterization and biological activity

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Abstract

Ru(III) complexes with pyrazine derivatives: 2,3-bis(2-pyridyl)pyrazine (DPP), pyrazine-2-amidoxime (PAOX), pyrazine-2-thiocarboxamide (PTCA) and 2-amino-5-bromo-3-(methylamino)pyrazine (ABMAP) have been prepared. Characterization of the compounds was acquired using UV-Vis and FT-IR spectroscopy, elemental analysis, conductivity and electrochemical measurements as well as thermogravimetric studies. The ligand field parameters, Δ0 (splitting parameter), B (Racah parameter of interelectronic repulsion) and β (nephelauxetic ratio) were calculated. The stabilities of the Ru(III) complexes have also been confirmed by spectrophotometric titration methods in acetonitrile and water solutions. The data showed that the examined compounds are stable both in solution and solid states, which was also confirmed by the values of their stability constants found. Moreover, the molecular structures of the complexes have been optimized using AM1 and PM3 methods and this supported octahedral geometry around the Ru(III) ion. The minimum inhibitory (MIC) and minimum bactericidal concentration (MBC) for synthesized complexes were studied against two Gram (+) bacteria, two Gram (−) bacteria and fungi – three reference strains of Candida albicans. The results show that [RuCl(PAOX)2(OH2)]Cl2 display antifungal activity.

Graphical abstract: Coordination chemistry of pyrazine derivatives analogues of PZA: design, synthesis, characterization and biological activity

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Publication details

The article was received on 02 Feb 2016, accepted on 21 May 2016 and first published on 23 May 2016


Article type: Paper
DOI: 10.1039/C6RA03068H
RSC Adv., 2016,6, 52009-52025
  • Open access: Creative Commons BY-NC license
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    Coordination chemistry of pyrazine derivatives analogues of PZA: design, synthesis, characterization and biological activity

    M. Ogryzek, A. Chylewska, A. Królicka, R. Banasiuk, K. Turecka, D. Lesiak, D. Nidzworski and M. Makowski, RSC Adv., 2016, 6, 52009
    DOI: 10.1039/C6RA03068H

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