Issue 91, 2016, Issue in Progress

Fabrication of complex PDMS microfluidic structures and embedded functional substrates by one-step injection moulding

Abstract

We report a novel injection moulding technique for fabrication of complex multi-layer microfluidic structures, allowing one-step robust integration of functional components with microfluidic channels, and fabrication of elastomeric microfluidic valves. This technique simplifies multi-layer microfluidic device fabrication, while significantly increasing device functionality. We demonstrate functional component integration through robust encapsulation of porous polyester membranes, in the context of an in vitro research platform intended to facilitate Blood Brain Barrier (BBB) research. We also demonstrate the fabrication of normally-closed, pneumatically actuated elastomer valves, integrated using the same one-step process. These valves are demonstrated in the context of variable flow resistors used to modulate flow in a pressure driven system.

Graphical abstract: Fabrication of complex PDMS microfluidic structures and embedded functional substrates by one-step injection moulding

Supplementary files

Article information

Article type
Paper
Submitted
17 Aug 2016
Accepted
04 Sep 2016
First published
08 Sep 2016

RSC Adv., 2016,6, 87988-87994

Fabrication of complex PDMS microfluidic structures and embedded functional substrates by one-step injection moulding

C. Szydzik, B. Niego, G. Dalzell, M. Knoerzer, F. Ball, W. S. Nesbitt, R. L. Medcalf, K. Khoshmanesh and A. Mitchell, RSC Adv., 2016, 6, 87988 DOI: 10.1039/C6RA20688C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements