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Issue 111, 2016, Issue in Progress
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Taste masking of a drug by pH-responsive coordination polymer-coated mesoporous silica nanoparticles

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Abstract

We developed a simple and efficient method for fabricating a taste-masked oral drug delivery system (DDS) that regulates the release of unpleasant drug taste via the change in pH value in the physiological environment of the alimentary canal. In this drug delivery system, a pH-sensitive metal–organic coordination polymer (CP), Fe-4,4′-bipyridine (Fe-bipy) complex, works as a taste-masker. The pH-sensitive Fe-bipy was grafted onto the mesoporous silica nanoparticles (MSNs) containing the model bitter drug mequindox (MEQ) in its mesopores through metal–organic coordination cross-linking, resulting in the CP-coated nanodrug MSN-NH2-MEQ@Fe-bipy. In artificial saliva (pH 6.6), Fe-4,4′-bipyridine CPs effectively prevent the leaking of the loaded guest molecule MEQ. On the other hand, in artificial gastric fluid (pH 1.0), the coordination bonds of the Fe-4,4′-bipyridine complex were broken, leading to the release of MEQ molecules from MSN-NH2-MEQ@Fe-bipy. The results indicate that the simple and efficient preparation method for taste-masked MSN-NH2-MEQ@Fe-bipy could provide new insights into taste-masking technology by using pH-responsive smart nanomaterials.

Graphical abstract: Taste masking of a drug by pH-responsive coordination polymer-coated mesoporous silica nanoparticles

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Supplementary files

Article information


Submitted
05 Aug 2016
Accepted
25 Oct 2016
First published
28 Oct 2016

RSC Adv., 2016,6, 109453-109459
Article type
Paper

Taste masking of a drug by pH-responsive coordination polymer-coated mesoporous silica nanoparticles

G. Bao, L. Wang, H. Yuan, X. Wang, T. Mei and M. Qu, RSC Adv., 2016, 6, 109453
DOI: 10.1039/C6RA19789B

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