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Issue 80, 2016
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Influence of high-mannose glycan whose glucose moiety is substituted with 5-thioglucose on calnexin/calreticulin cycle

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Abstract

Our study first revealed that UDP-5-thioglucose functions as a glycosyl donor of UDP-glucose: glycoprotein glucosyltransferase to produce 5-thio-glucosylated Man9 (5S-G1M9). Subsequently, we observed that only calreticulin can interact with 5S-G1M9. Finally, the 5-thioglucose residue was resistant to hydrolysis by glucosidase II.

Graphical abstract: Influence of high-mannose glycan whose glucose moiety is substituted with 5-thioglucose on calnexin/calreticulin cycle

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Publication details

The article was received on 26 Jun 2016, accepted on 09 Aug 2016 and first published on 09 Aug 2016


Article type: Communication
DOI: 10.1039/C6RA16476E
RSC Adv., 2016,6, 76879-76882

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    Influence of high-mannose glycan whose glucose moiety is substituted with 5-thioglucose on calnexin/calreticulin cycle

    M. Sakono, A. Seko, Y. Takeda, M. Hachisu, A. Koizumi, K. Fujikawa, H. Seto and Y. Ito, RSC Adv., 2016, 6, 76879
    DOI: 10.1039/C6RA16476E

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