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Issue 82, 2016, Issue in Progress
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Room temperature copper-catalyzed oxidative amidation of terminal alkynes for the synthesis of α-ketoamides using O-benzoyl hydroxylamines as aminating reagent and oxidant

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Abstract

A novel and convenient copper-catalyzed oxidative amidation for the synthesis of α-ketoamides has been successfully developed, which uses easily available O-benzoyl hydroxylamines as aminating reagent and oxidant. The reaction proceeds smoothly at room temperature and is compatible with a range of substrates to give the desired products in moderate to good yields.

Graphical abstract: Room temperature copper-catalyzed oxidative amidation of terminal alkynes for the synthesis of α-ketoamides using O-benzoyl hydroxylamines as aminating reagent and oxidant

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Publication details

The article was received on 12 Jun 2016, accepted on 10 Aug 2016 and first published on 11 Aug 2016


Article type: Communication
DOI: 10.1039/C6RA15219H
RSC Adv., 2016,6, 78307-78310

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    Room temperature copper-catalyzed oxidative amidation of terminal alkynes for the synthesis of α-ketoamides using O-benzoyl hydroxylamines as aminating reagent and oxidant

    G. Shen, L. zhao, Y. Wang and T. Zhang, RSC Adv., 2016, 6, 78307
    DOI: 10.1039/C6RA15219H

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