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Issue 76, 2016
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Fe3O4@Pt/MWCNT/carbon paste electrode for determination of a doxorubicin anticancer drug in a human urine sample

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Abstract

In this study, a Fe3O4@Pt nanoparticle and multi-walled carbon nanotube (MWCNT) modified carbon paste electrode was used as a fast and sensitive tool for the electrochemical determination of doxorubicin (DOX). The electrochemical oxidation of DOX was investigated at Fe3O4@Pt/MWCNT/CPE using the differential pulse voltammetry method. The developed electrode exhibited excellent electrochemical activity towards the electrochemical oxidation of the investigated anticancer drug. Under the optimized experimental conditions, a linear calibration curve in the range of 0.05 to 70.0 μmol L−1 with two different slopes and a detection limit of 1 nmol L−1 was obtained. Finally, the method was successfully employed for the voltammetric determination of DOX in a urine sample at trace levels with good recoveries.

Graphical abstract: Fe3O4@Pt/MWCNT/carbon paste electrode for determination of a doxorubicin anticancer drug in a human urine sample

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Article information


Submitted
29 May 2016
Accepted
13 Jul 2016
First published
27 Jul 2016

RSC Adv., 2016,6, 72803-72809
Article type
Paper

Fe3O4@Pt/MWCNT/carbon paste electrode for determination of a doxorubicin anticancer drug in a human urine sample

T. Madrakian, K. D. Asl, M. Ahmadi and A. Afkhami, RSC Adv., 2016, 6, 72803
DOI: 10.1039/C6RA13935C

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