Issue 88, 2016, Issue in Progress
From the journal:

RSC Advances

Cu(ii)-catalyzed cross-dehydrogenative coupling reaction of N′-acyl arylhydrazines and phosphites†

Ji-Quan Zhang,ac   Yan-Shi Xiong,a   Albert S. C. Chana  and  Gui Lu*ab  

* Corresponding authors

a Institute of Medicinal Chemistry, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, P. R. China
E-mail: lugui@mail.sysu.edu.cn
Fax: +86-20-39943048

b Institute of Human Virology, Sun Yat-sen University, Guangzhou, P. R. China

c College of Pharmacy, Guizhou Medical University, Guiyang, P. R. China

Abstract

A novel Cu(II)-catalyzed cross-dehydrogenative coupling reaction of N′-aryl acylhydrazines and dialkyl phosphites has been developed for the synthesis of phosphorylhydrazides by using NMO as an external oxidant and AgNO3 as additive. Various N′-aryl acylhydrazines were mildly and regioselectively converted to corresponding phosphorylhydrazides with good to excellent yields.

Graphical abstract: Cu(ii)-catalyzed cross-dehydrogenative coupling reaction of N′-acyl arylhydrazines and phosphites

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Article information

DOI
https://doi.org/10.1039/C6RA13931K
Article type
Paper
Submitted
29 May 2016
Accepted
31 Aug 2016
First published
31 Aug 2016

RSC Adv., 2016,6, 84587-84591

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Cu(II)-catalyzed cross-dehydrogenative coupling reaction of N′-acyl arylhydrazines and phosphites

J. Zhang, Y. Xiong, A. S. C. Chan and G. Lu, RSC Adv., 2016, 6, 84587 DOI: 10.1039/C6RA13931K

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