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Issue 47, 2016, Issue in Progress
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Rhodium-catalysed tandem dehydrogenative coupling–Michael addition: direct synthesis of phthalides from benzoic acids and alkenes

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Abstract

[(COD)RhCl]2 catalyses the coupling of benzoic acids and alkenes in the presence of Cu(OAc)2·H2O and dicyclopentadiene to afford phthalides in 15–93% yield. A 3-substituted or 3,7-disubstituted product is obtained selectively depending on alkene type. The reaction is highly atom-economical and uses readily available starting materials.

Graphical abstract: Rhodium-catalysed tandem dehydrogenative coupling–Michael addition: direct synthesis of phthalides from benzoic acids and alkenes

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Article information


Submitted
23 Mar 2016
Accepted
17 Apr 2016
First published
22 Apr 2016

RSC Adv., 2016,6, 40626-40630
Article type
Communication

Rhodium-catalysed tandem dehydrogenative coupling–Michael addition: direct synthesis of phthalides from benzoic acids and alkenes

A. Renzetti, H. Nakazawa and C. Li, RSC Adv., 2016, 6, 40626 DOI: 10.1039/C6RA07671H

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