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Issue 54, 2016, Issue in Progress
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Advances in exploring alternative Taxol sources

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The protection and sustainable utilization of natural resources are among the most pressing global problems of the 21st century. Taxol is a well-known anticancer agent with a unique active mechanism, mainly isolated from the slow-growing yew tree, which has achieved the status of “blockbuster drug” due to its popularity in the treatment of cancers. However, the source of Taxol has always been a primary concern, because its content in the plant is extremely low. In this review, we introduce the advances in exploring alternative Taxol sources aside from total synthesis, including Taxol from nursery cultivated Taxus, semi-synthesis of Taxol, Taxol from Taxus cell culture, production of Taxol by synthetic biology, Taxol from the endophytic fungi and Taxol from other non-Taxus plants. The future perspective of Taxol production is also discussed.

Graphical abstract: Advances in exploring alternative Taxol sources

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The article was received on 13 Mar 2016, accepted on 02 May 2016 and first published on 13 May 2016

Article type: Review Article
DOI: 10.1039/C6RA06640B
RSC Adv., 2016,6, 48800-48809

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    Advances in exploring alternative Taxol sources

    W. C. Liu, T. Gong and P. Zhu, RSC Adv., 2016, 6, 48800
    DOI: 10.1039/C6RA06640B

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