Jump to main content
Jump to site search

Issue 57, 2016, Issue in Progress
Previous Article Next Article

Synthesis of tailor-made bile acid sequestrants by supplemental activator and reducing agent atom transfer radical polymerization

Author affiliations

Abstract

This work reports the synthesis of tailor-made polymeric bile acid sequestrants (BAS) by supplemental activator and reducing agent atom transfer radical polymerization (SARA ATRP) using ecofriendly conditions. The new materials were based on amphiphilic poly(methyl acrylate)-b-poly((3-acrylamidopropyl)trimethylammonium chloride) (PMA-b-PAMPTMA) star block copolymers and cationic hydrogels (PAMPTMA). The in vitro sequestration ability of the polymers was investigated in simulated intestinal fluid using sodium cholate (NaCA) as the bile salt model molecule. Both polymeric structures investigated showed higher affinity towards NaCA micelles than unimers. The cationic hydrogels proved to be attractive BAS candidates, with binding parameters similar to those of the most effective commercial BAS: Colesevelam hydrochloride. Several polymer features were investigated for the star block copolymers in order to understand the structure/performance relationship. It was found that the binding parameters can be tuned by targeting different compositions of the block copolymers and, typically, longer cationic arms led to enhanced binding capacity.

Graphical abstract: Synthesis of tailor-made bile acid sequestrants by supplemental activator and reducing agent atom transfer radical polymerization

Back to tab navigation

Supplementary files

Article information


Submitted
07 Mar 2016
Accepted
20 May 2016
First published
23 May 2016

RSC Adv., 2016,6, 52143-52153
Article type
Paper

Synthesis of tailor-made bile acid sequestrants by supplemental activator and reducing agent atom transfer radical polymerization

P. V. Mendonça, M. J. Moreno, A. C. Serra, S. Simões and J. F. J. Coelho, RSC Adv., 2016, 6, 52143
DOI: 10.1039/C6RA06087K

Social activity

Search articles by author

Spotlight

Advertisements