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Issue 80, 2016, Issue in Progress
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In vivo drug release behavior and osseointegration of a doxorubicin-loaded tissue-engineered scaffold

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Abstract

Bone tissue-engineered scaffolds with therapeutic effects must meet the basic requirements as to support bone healing at the defect side and to release an effect drug within the therapeutic window. Here, a rapid prototyped PCL scaffold embedded with a chitosan/nanoclay/β-tricalcium phosphate composite (DESCLAYMR) loaded with the chemotherapeutic drug doxorubicin (DESCLAYMR_DOX) is proposed as a potential multifunctional medical application for patients who undergo bone tumor resection. We showed the DESCLAYMR_DOX scaffold released DOX locally in a sustained manner in mice without significantly increasing the plasma DOX concentrations. The evaluation of osseointegration in a porcine study showed increased mineralized bone formation, unmineralized collagen fibers and significantly higher alpha Smooth Muscle Actin (α-SMA) positive areas relative to the total investigated area (TA) in defects treated solely with the DESCLAYMR scaffold than in the DESCLAYMR_DOX; and alkaline phosphatase activity, α-SMA/TA and bone formation were higher in the DESCLAYMR loaded with 100 μg per scaffold DOX (DOX_low) than with 400 μg per scaffold DOX (DOX_high). Our results suggest that the DESCLAYMR_DOX can be a viable candidate as a multifunctional medical application by delivering the chemotherapeutic agent to target remaining tumor cells and facilitate bone formation.

Graphical abstract: In vivo drug release behavior and osseointegration of a doxorubicin-loaded tissue-engineered scaffold

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Publication details

The article was received on 29 Feb 2016, accepted on 01 Aug 2016 and first published on 08 Aug 2016


Article type: Paper
DOI: 10.1039/C6RA05351C
RSC Adv., 2016,6, 76237-76245

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    In vivo drug release behavior and osseointegration of a doxorubicin-loaded tissue-engineered scaffold

    M. Sun, M. Chen, M. Wang, J. Hansen, A. Baatrup, F. Dagnaes-Hansen, J. H. D. Rölfing, J. Jensen, H. Lysdahl, H. Li, M. Johannsen, D. Q. S. Le, J. Kjems and C. E. Bünger, RSC Adv., 2016, 6, 76237
    DOI: 10.1039/C6RA05351C

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