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Issue 32, 2016
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Nanoscale graphene coating on commercially pure titanium for accelerated bone regeneration

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Abstract

Titanium (Ti) is one of the representative biocompatible metallic materials which has been widely exploited for various implants and bone replacements. Here, commercially pure Ti (CP Ti) was surface-modified with reduced graphene oxide (RGO) for accelerated bone regeneration and osseointegration. Nanoscale RGO coating on CP Ti was clearly confirmed by SEM, AFM, EDS, XPS, HR-TEM and EELS. In addition, pre-osteoblast cells cultured on RGO-CP Ti showed higher cell viability and cell attachment than those on CP Ti. After confirmation of the drug loading capability of RGO-CP Ti, osteogenic dexamethasone loaded RGO-CP Ti (Dex/RGO-CP Ti) was implanted on calvarial bone defects in rats. Synchrotron X-ray imaging successfully visualized more effective bone regeneration on Dex/RGO-CP Ti than CP Ti and RGO-CP Ti after 8 weeks.

Graphical abstract: Nanoscale graphene coating on commercially pure titanium for accelerated bone regeneration

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Supplementary files

Article information


Submitted
12 Feb 2016
Accepted
02 Mar 2016
First published
04 Mar 2016

This article is Open Access

RSC Adv., 2016,6, 26719-26724
Article type
Communication

Nanoscale graphene coating on commercially pure titanium for accelerated bone regeneration

H. S. Jung, Y. Choi, J. Jeong, Y. Lee, B. Hwang, J. Jang, J. Shim, Y. S. Kim, H. S. Choi, S. H. Oh, C. S. Lee, D. Cho and S. K. Hahn, RSC Adv., 2016, 6, 26719
DOI: 10.1039/C6RA03905G

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material and it is not used for commercial purposes.

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    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
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    [Original citation] - Published by the PCCP Owner Societies.
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    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
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    [Original citation] - Published by The Royal Society of Chemistry.

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