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Issue 46, 2016, Issue in Progress
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Phosphorescent oxygen-sensing and singlet oxygen production by a biosynthetic silk

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Abstract

A recombinant coiled-coil silk was utilised to immobilise heavy-metal-macrocycles which are known to undergo efficient intersystem crossing from the singlet state to the triplet state following excitation with visible light. This spin-forbidden transition leads to phosphorescence and the production of cytotoxic oxygen species. We explore the requirements for specific binding of these macrocycles and demonstrate that immobilisation does not adversely affect their photochemical properties. The biocompatible materials developed here have potential biomedical applications in photodynamic therapy (PDT) and dynamic oxygen-sensing.

Graphical abstract: Phosphorescent oxygen-sensing and singlet oxygen production by a biosynthetic silk

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Supplementary files

Article information


Submitted
10 Feb 2016
Accepted
10 Apr 2016
First published
12 Apr 2016

This article is Open Access

RSC Adv., 2016,6, 39530-39533
Article type
Communication

Phosphorescent oxygen-sensing and singlet oxygen production by a biosynthetic silk

C. C. Horgan, Y. Han, H. Trueman, C. J. Jackson, T. D. Sutherland and T. D. Rapson, RSC Adv., 2016, 6, 39530
DOI: 10.1039/C6RA03731C

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