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Issue 36, 2016, Issue in Progress
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PEG-modified upconversion nanoparticles for in vivo optical imaging of tumors

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Abstract

A novel surface modification approach of brightly luminescent upconversion nanoparticles (UCNPs) is reported. Inorganic core@shell UCNPs (core – NaYF4 co-doped with Yb3+ and Tm3+ ions, shell – NaYF4) were modified by intercalation with amphiphilic copolymer poly(maleic anhydride-alt-1-octadecene) followed by cross-linking with poly(ethylene glycol) diglycidyl ether (PEG-DGE). The proposed approach enables preparation of UCNPs with an outmost PEG-containing layer, which provides steric stabilization and low non-specific protein adsorption. Intravenous injection of PEG-functionalized UCNPs into the mice results in extension of the UCNP blood circulation time up to 1 hour. In vivo epi-luminescence imaging of the mouse model with Lewis lung carcinoma is ensured by the high quantum yield of the modified UCNPs and passive targeting associated with efficient UCNP accumulation in solid tumors.

Graphical abstract: PEG-modified upconversion nanoparticles for in vivo optical imaging of tumors

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Publication details

The article was received on 28 Nov 2015, accepted on 16 Mar 2016 and first published on 17 Mar 2016


Article type: Paper
DOI: 10.1039/C5RA25304G
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RSC Adv., 2016,6, 30089-30097

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    PEG-modified upconversion nanoparticles for in vivo optical imaging of tumors

    A. N. Generalova, V. V. Rocheva, A. V. Nechaev, D. A. Khochenkov, N. V. Sholina, V. A. Semchishen, V. P. Zubov, A. V. Koroleva, B. N. Chichkov and E. V. Khaydukov, RSC Adv., 2016, 6, 30089
    DOI: 10.1039/C5RA25304G

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