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Issue 10, 2016
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Qualitative analysis of chiral alanine by UV-visible-shortwave near infrared diffuse reflectance spectroscopy combined with chemometrics

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Abstract

UV-visible-shortwave near infrared diffuse reflectance spectroscopy (UV-vis-SWNIR DRS) combined with chemometrics is investigated for the first time to discriminate enantiomers and their racemic compounds, using D-, L- and DL-alanine as model compounds. After optimizing the measuring conditions of powder particle sizes and the distance between fiber probe and sample, discriminant partial least squares (PLS-DA) models were built with UV-vis-SWNIR DRS to implement the qualitative analysis of alanine chirality. As a result, under the optimized conditions of particle size sifted through 100-mesh and a distance of 5.3 mm, an excellent discrimination of chirality with an accuracy of 100% was obtained, which is better than that of manufacturers with an accuracy of 86.67%. The results of this study infer that UV-vis-SWNIR DRS combined with chemometrics can be a rapid, simple and noninvasive method for chiral analysis.

Graphical abstract: Qualitative analysis of chiral alanine by UV-visible-shortwave near infrared diffuse reflectance spectroscopy combined with chemometrics

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Article information


Submitted
27 Oct 2015
Accepted
06 Jan 2016
First published
12 Jan 2016

RSC Adv., 2016,6, 8395-8405
Article type
Paper
Author version available

Qualitative analysis of chiral alanine by UV-visible-shortwave near infrared diffuse reflectance spectroscopy combined with chemometrics

X. Li, K. Xu, H. Li, S. Yao, Y. Li and B. Liang, RSC Adv., 2016, 6, 8395
DOI: 10.1039/C5RA22488H

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