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Issue 1, 2016
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Regioselective α-arylation of coumarins and 2-pyridones with phenylhydrazines under transition-metal-free conditions

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Abstract

A facile regioselective metal-free direct α-arylation of coumarins and 2-pyridones is achieved by the reaction of coumarins and 2-pyridones with phenylhydrazine in good yields. The reaction proceeds at room temperature under mild conditions using inexpensive reagents and without the need for step intensive activating groups. The methodology is operationally simple, practically viable and also allows the coupling of similar nitrogen heterocycle aza-coumarins without prerequisite N-protection.

Graphical abstract: Regioselective α-arylation of coumarins and 2-pyridones with phenylhydrazines under transition-metal-free conditions

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Article information


Submitted
09 Oct 2015
Accepted
10 Dec 2015
First published
15 Dec 2015

RSC Adv., 2016,6, 109-118
Article type
Paper
Author version available

Regioselective α-arylation of coumarins and 2-pyridones with phenylhydrazines under transition-metal-free conditions

P. Chauhan, M. Ravi, S. Singh, P. Prajapati and P. P. Yadav, RSC Adv., 2016, 6, 109
DOI: 10.1039/C5RA20954D

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