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Issue 11, 2016
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Manganese-catalyzed ring-opening chlorination of cyclobutanols: regiospecific synthesis of γ-chloroketones

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Abstract

We disclose an efficient manganese-catalyzed ring-opening chlorination of cyclobutanols. This reaction has a broad substrate scope, affording a variety of γ-chloro alkyl ketones and medium-sized benzocyclic chlorides in synthetically useful yields and unique regioselectivities. The merits including mild reaction conditions and employment of inexpensive catalysts and reagents make it a practical approach for the production of γ-chlorinated ketones.

Graphical abstract: Manganese-catalyzed ring-opening chlorination of cyclobutanols: regiospecific synthesis of γ-chloroketones

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Article information


Submitted
06 Aug 2016
Accepted
03 Sep 2016
First published
05 Sep 2016

Org. Chem. Front., 2016,3, 1467-1471
Article type
Research Article

Manganese-catalyzed ring-opening chlorination of cyclobutanols: regiospecific synthesis of γ-chloroketones

L. Huan and C. Zhu, Org. Chem. Front., 2016, 3, 1467
DOI: 10.1039/C6QO00443A

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