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Issue 45, 2016
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Nanoparticles highly loaded with gentamicin sulfate by a combination of polyhydroxylated macromonomers and ROMP for the synthesis of bioactive biomaterials

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Abstract

Antibiotic functionalized polymeric nanoparticles (NPs) are obtained by the copolymerization of macromonomers, which is a powerful way to synthesize bioactive biomaterial surfaces able to fight a bacterial strain in the case of infection. The active molecule loading can be modulated/increased by the use of highly charged macromonomers (typically polyhydroxylated macromonomers). This paper presents the synthesis of α-norbornenyl hydroxylated macromonomers (polyglycidol and poly(ethylene oxide)-block-polyglycidol) functionalized with an antibiotic: gentamicin sulfate. Then, these macromonomers are copolymerized with norbornene (Nb) by ring-opening metathesis polymerization in a dispersion to form core–shell NPs which have application as antibiotic platforms for the synthesis of bioactive biomaterial surfaces.

Graphical abstract: Nanoparticles highly loaded with gentamicin sulfate by a combination of polyhydroxylated macromonomers and ROMP for the synthesis of bioactive biomaterials

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Publication details

The article was received on 11 Oct 2016, accepted on 25 Oct 2016 and first published on 25 Oct 2016


Article type: Paper
DOI: 10.1039/C6PY01774F
Polym. Chem., 2016,7, 7019-7028

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    Nanoparticles highly loaded with gentamicin sulfate by a combination of polyhydroxylated macromonomers and ROMP for the synthesis of bioactive biomaterials

    L. Pichavant, H. Carrié, M. C. Durrieu and V. Héroguez, Polym. Chem., 2016, 7, 7019
    DOI: 10.1039/C6PY01774F

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