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Issue 13, 2016
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Core functionalization of semi-crystalline polymeric cylindrical nanoparticles using photo-initiated thiol–ene radical reactions

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Abstract

Sequential ring-opening and reversible addition–fragmentation chain transfer (RAFT) polymerization was used to form a triblock copolymer of tetrahydropyran acrylate (THPA), 5-methyl-5-allyloxycarbonyl-1,3-dioxan-2-one (MAC) and L-lactide. Concurrent deprotection of the THPA block and crystallization-driven self-assembly (CDSA) was undertaken and allowed for the formation of cylindrical micelles bearing allyl handles in a short outer core segment. These handles were further functionalized by different thiols using photo-initiated thiol–ene radical reactions to demonstrate that the incorporation of an amorphous PMAC block within the core does not disrupt CDSA and can be used to load the cylindrical nanoparticles with cargo.

Graphical abstract: Core functionalization of semi-crystalline polymeric cylindrical nanoparticles using photo-initiated thiol–ene radical reactions

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Publication details

The article was received on 10 Dec 2015, accepted on 12 Feb 2016 and first published on 25 Feb 2016


Article type: Paper
DOI: 10.1039/C5PY01970B
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Polym. Chem., 2016,7, 2337-2341
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    Core functionalization of semi-crystalline polymeric cylindrical nanoparticles using photo-initiated thiol–ene radical reactions

    L. Sun, A. Pitto-Barry, A. W. Thomas, M. Inam, K. Doncom, A. P. Dove and R. K. O'Reilly, Polym. Chem., 2016, 7, 2337
    DOI: 10.1039/C5PY01970B

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