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Issue 4, 2016
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Micelles from self-assembled double-hydrophilic PHEMA-glycopolymer-diblock copolymers as multivalent scaffolds for lectin binding

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Abstract

We introduce a novel double-hydrophilic hydroxyethylmethacrylate (HEMA) based diblock glycopolymer which self-assembles into homogeneous spherical micellar structures in water. The micellar structure renders surface-oriented N-acetylglucocosamine (GlcNAc) sugar moieties for strong multivalent glycan-mediated lectin binding. Structural analysis and lectin binding is performed by microscopy methods, dynamic light scattering (DLS) and two-focus fluorescence correlation spectroscopy (2fFCS), revealing a novel micellar type of multivalent sugar binding scaffold with high potential for biomedical applications.

Graphical abstract: Micelles from self-assembled double-hydrophilic PHEMA-glycopolymer-diblock copolymers as multivalent scaffolds for lectin binding

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Supplementary files

Article information


Submitted
26 May 2015
Accepted
30 Nov 2015
First published
02 Dec 2015

Polym. Chem., 2016,7, 878-886
Article type
Paper

Micelles from self-assembled double-hydrophilic PHEMA-glycopolymer-diblock copolymers as multivalent scaffolds for lectin binding

H. Park, S. Walta, R. R. Rosencrantz, A. Körner, C. Schulte, L. Elling, W. Richtering and A. Böker, Polym. Chem., 2016, 7, 878
DOI: 10.1039/C5PY00797F

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