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Issue 27, 2016
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Overproduction and identification of butyrolactones SCB1–8 in the antibiotic production superhost Streptomyces M1152

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Abstract

Gamma-butyrolactones (GBLs) are signalling molecules that control antibiotic production in Streptomyces bacteria. The genetically engineered strain S. coelicolor M1152 was found to overproduce GBLs SCB1–3 as well as five novel GBLs named SCB4–8. Incorporation experiments using isotopically-labelled precursors confirmed the chemical structures of SCB1–3 and established those of SCB4–8.

Graphical abstract: Overproduction and identification of butyrolactones SCB1–8 in the antibiotic production superhost Streptomyces M1152

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Supplementary files

Article information


Submitted
19 Apr 2016
Accepted
10 May 2016
First published
10 May 2016

This article is Open Access

Org. Biomol. Chem., 2016,14, 6390-6393
Article type
Communication
Author version available

Overproduction and identification of butyrolactones SCB1–8 in the antibiotic production superhost Streptomyces M1152

J. D. Sidda, V. Poon, L. Song, W. Wang, K. Yang and C. Corre, Org. Biomol. Chem., 2016, 14, 6390
DOI: 10.1039/C6OB00840B

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