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Issue 15, 2016
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Multicomponent access to indolo[3,3a-c]isoquinolin-3,6-diones: formal synthesis of (±)-plicamine

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Abstract

The complete tetracyclic core structure of plicamine, a novel Amaryllidaceae-type alkaloid, was expeditously prepared by a Ugi four-component condensation reaction, followed by a one-pot sequential phenolic oxidation and intramolecular coupling process. The employment of this strategy resulted in a rapid, formal synthesis of (±)-plicamine.

Graphical abstract: Multicomponent access to indolo[3,3a-c]isoquinolin-3,6-diones: formal synthesis of (±)-plicamine

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Publication details

The article was received on 27 Jan 2016, accepted on 14 Mar 2016 and first published on 14 Mar 2016


Article type: Communication
DOI: 10.1039/C6OB00231E
Org. Biomol. Chem., 2016,14, 3677-3680

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    Multicomponent access to indolo[3,3a-c]isoquinolin-3,6-diones: formal synthesis of (±)-plicamine

    M. V. Mijangos and L. D. Miranda, Org. Biomol. Chem., 2016, 14, 3677
    DOI: 10.1039/C6OB00231E

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