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Issue 46, 2016
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Total synthesis, structural elucidation and anti-inflammatory activity evaluation of 2-deoxy-3,6-anhydro hexofuranoside derivatives isolated from Sauropus rostratus

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Abstract

The first total synthesis of four 2-deoxy-3,6-anhydro hexofuranoside derivatives, namely sauropunols (A–D), isolated from the traditional Chinese medicinal plant Sauropus rostratus was accomplished. Structures of sauropunols A and B were clearly elucidated and reassigned. The anti-inflammatory activities of sauropunols (A–D) as well as the synthetic intermediates were evaluated, which is valuable for further structure–activity relationship (SAR) studies on this class of natural products.

Graphical abstract: Total synthesis, structural elucidation and anti-inflammatory activity evaluation of 2-deoxy-3,6-anhydro hexofuranoside derivatives isolated from Sauropus rostratus

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Article information


Submitted
10 Oct 2016
Accepted
27 Oct 2016
First published
31 Oct 2016

Org. Biomol. Chem., 2016,14, 10906-10913
Article type
Paper

Total synthesis, structural elucidation and anti-inflammatory activity evaluation of 2-deoxy-3,6-anhydro hexofuranoside derivatives isolated from Sauropus rostratus

C. Zhang, C. Wang, Z. Wang, G. Tanabe, O. Muraoka, A. Lin, J. Xu, X. Wu, L. Wu and W. Xie, Org. Biomol. Chem., 2016, 14, 10906
DOI: 10.1039/C6OB02207C

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