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Issue 48, 2016
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Macrolactam analogues of macrolide natural products

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Abstract

The chemical modification of macrolide natural products into aza- or lactam analogues is a strategy employed to improve their metabolic stability and biological activity. The methods for the synthesis of several lactam analogues of macrolide natural products are highlighted and aspects of their biological properties presented.

Graphical abstract: Macrolactam analogues of macrolide natural products

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Article information


Submitted
03 Oct 2016
Accepted
27 Oct 2016
First published
27 Oct 2016

Org. Biomol. Chem., 2016,14, 11301-11316
Article type
Review Article

Macrolactam analogues of macrolide natural products

H. M. Hügel, A. T. Smith and M. A. Rizzacasa, Org. Biomol. Chem., 2016, 14, 11301
DOI: 10.1039/C6OB02149B

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