Issue 38, 2016
From the journal:

Organic & Biomolecular Chemistry

Synthesis and antiproliferative activity of new tonantzitlolone-derived diterpene derivatives†

Torsten Busch,a   Gerald Dräger,a   Eike Kunst,a   Hannah Benson,a   Florenz Sasse,b   Karsten Siemsc  and  Andreas Kirschning*a  

* Corresponding authors

a Institut für Organische Chemie and Biomolekulares Wirkstoffzentrum (BMWZ), Leibniz Universität Hannover, Schneiderberg 1b, 30167 Hannover, Germany
E-mail: andreas.kirschning@oci.uni-hannover.de
Fax: +49 (0)511-7623011
Tel: +49 (0)511-7624614

b Helmholtz Zentrum für Infektionsforschung (HZI), Inhoffenstrasse 7, 38124 Braunschweig, Germany

c AnalytiCon Discovery GmbH, Hermannswerder Haus 17, 14473 Potsdam, Germany

Abstract

The synthesis of the diterpene (+)-tonantzitlolone A and a series of derivatives is reported. The study includes the determination of their antiproliferative activities against selected cancer cell lines.

Graphical abstract: Synthesis and antiproliferative activity of new tonantzitlolone-derived diterpene derivatives

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Article information

DOI
https://doi.org/10.1039/C6OB01697A
Article type
Paper
Submitted
06 Aug 2016
Accepted
30 Aug 2016
First published
30 Aug 2016

Org. Biomol. Chem., 2016,14, 9040-9045

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Synthesis and antiproliferative activity of new tonantzitlolone-derived diterpene derivatives

T. Busch, G. Dräger, E. Kunst, H. Benson, F. Sasse, K. Siems and A. Kirschning, Org. Biomol. Chem., 2016, 14, 9040 DOI: 10.1039/C6OB01697A

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