Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 38, 2016
Previous Article Next Article

Total synthesis of diptoindonesin G and its analogues as selective modulators of estrogen receptors

Author affiliations

Abstract

We have developed a versatile synthetic strategy for the synthesis of the natural product diptoindonesin G and its analogues as selective modulators of estrogen receptors. The strategy involves a regioselective dehydrative cyclization of arylacetals, a regioselective bromination of benzofurans, a sequential cross-coupling of bromo-benzofurans with aryl boronic acids, and a BBr3-mediated tandem cyclization and demethylation. Preliminary biological studies uncovered the critical and dispensable phenolic hydroxyl groups in the natural product and also revealed unexpected selectivity for isoforms of estrogen receptor.

Graphical abstract: Total synthesis of diptoindonesin G and its analogues as selective modulators of estrogen receptors

Back to tab navigation

Supplementary files

Article information


Submitted
01 Aug 2016
Accepted
05 Sep 2016
First published
12 Sep 2016

Org. Biomol. Chem., 2016,14, 8927-8930
Article type
Communication

Total synthesis of diptoindonesin G and its analogues as selective modulators of estrogen receptors

J. Liu, T. J. Do, C. J. Simmons, J. C. Lynch, W. Gu, Z. Ma, W. Xu and W. Tang, Org. Biomol. Chem., 2016, 14, 8927
DOI: 10.1039/C6OB01657J

Social activity

Search articles by author

Spotlight

Advertisements