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Issue 36, 2016
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Organophosphorus-mediated N–N bond formation: facile access to 3-amino-2H-indazoles

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Abstract

A convenient and efficient strategy has been devised to access 3-amino-2H-indazole derivatives in two steps from readily available starting materials. The conversion of 2-nitrobenzonitriles to substituted benzamidines followed by an organophosphorus-mediated reductive cyclization and a subsequent N–N bond formation afforded 3-amino-2H-indazoles in good to excellent yields.

Graphical abstract: Organophosphorus-mediated N–N bond formation: facile access to 3-amino-2H-indazoles

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Publication details

The article was received on 19 Jul 2016, accepted on 15 Aug 2016 and first published on 15 Aug 2016


Article type: Paper
DOI: 10.1039/C6OB01544A
Org. Biomol. Chem., 2016,14, 8520-8528

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    Organophosphorus-mediated N–N bond formation: facile access to 3-amino-2H-indazoles

    H. Bel Abed, J. Schoene, M. Christmann and M. Nazaré, Org. Biomol. Chem., 2016, 14, 8520
    DOI: 10.1039/C6OB01544A

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