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Issue 32, 2016
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Convergent synthesis of oligosaccharides on the gram-scale using cetyl thioglycoside based on a hydrophobically assisted switching phase method

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Abstract

A hydrophobically assisted switching phase (HASP) method is an efficient strategy for the synthesis of carrier-loaded oligosaccharides. We improved this method by using cetyl thioglycoside as the carrier, which made it possible to use the synthetic oligosaccharide block directly as the donor. We applied this improved HASP method in the successful assembly of a gp120-associated nona-mannoside. Our results indicated that the HASP method is an efficient strategy for the synthesis of complex oligosaccharides and glycoconjugates.

Graphical abstract: Convergent synthesis of oligosaccharides on the gram-scale using cetyl thioglycoside based on a hydrophobically assisted switching phase method

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Publication details

The article was received on 11 Jun 2016, accepted on 20 Jul 2016 and first published on 20 Jul 2016


Article type: Paper
DOI: 10.1039/C6OB01267A
Org. Biomol. Chem., 2016,14, 7722-7730

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    Convergent synthesis of oligosaccharides on the gram-scale using cetyl thioglycoside based on a hydrophobically assisted switching phase method

    S. Meng, T. Tian, Y. Wang, X. Meng and Z. Li, Org. Biomol. Chem., 2016, 14, 7722
    DOI: 10.1039/C6OB01267A

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