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Issue 25, 2016
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Total synthesis of desoxycyclomarin C and the cyclomarazines A and B

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Abstract

Removing the β-hydroxy group from the prenylated tryptophan moiety of cyclomarins simplifies the synthesis of these interesting natural products significantly, without having a noteworthy effect on the anti-tuberculosis activity of the cyclomarins. In contrast, cyclomarazines did not show biological activity.

Graphical abstract: Total synthesis of desoxycyclomarin C and the cyclomarazines A and B

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Supplementary files

Article information


Submitted
14 Apr 2016
Accepted
19 May 2016
First published
31 May 2016

Org. Biomol. Chem., 2016,14, 6055-6064
Article type
Paper

Total synthesis of desoxycyclomarin C and the cyclomarazines A and B

P. Barbie and U. Kazmaier, Org. Biomol. Chem., 2016, 14, 6055
DOI: 10.1039/C6OB00801A

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