Issue 25, 2016

Recent applications in natural product synthesis of dihydrofuran and -pyran formation by ring-closing alkene metathesis

Abstract

In the past two decades, alkene metathesis has risen in prominence to become a significant synthetic strategy for alkene formation. Many total syntheses of natural products have used this transformation. We review the use, from 2003 to 2015, of ring-closing alkene metathesis (RCM) for the generation of dihydrofurans or -pyrans in natural product synthesis. The strategies used to assemble the RCM precursors and the subsequent use of the newly formed unsaturation will also be highlighted and placed in context.

Graphical abstract: Recent applications in natural product synthesis of dihydrofuran and -pyran formation by ring-closing alkene metathesis

Article information

Article type
Review Article
Submitted
18 Mar 2016
Accepted
13 Apr 2016
First published
25 Apr 2016
This article is Open Access
Creative Commons BY license

Org. Biomol. Chem., 2016,14, 5875-5893

Author version available

Recent applications in natural product synthesis of dihydrofuran and -pyran formation by ring-closing alkene metathesis

R. Jacques, R. Pal, N. A. Parker, C. E. Sear, P. W. Smith, A. Ribaucourt and D. M. Hodgson, Org. Biomol. Chem., 2016, 14, 5875 DOI: 10.1039/C6OB00593D

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