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Issue 18, 2016
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A convenient enantioselective CBS-reduction of arylketones in flow-microreactor systems

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Abstract

A convenient, versatile, and green CBS-asymmetric reduction of aryl and heteroaryl ketones has been developed by using the microreactor technology. The study demonstrates that it is possible to handle borane solution safely within microreactors and that the reaction performs well using 2-MeTHF as a greener solvent.

Graphical abstract: A convenient enantioselective CBS-reduction of arylketones in flow-microreactor systems

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Publication details

The article was received on 11 Feb 2016, accepted on 06 Apr 2016 and first published on 06 Apr 2016


Article type: Paper
DOI: 10.1039/C6OB00336B
Org. Biomol. Chem., 2016,14, 4304-4311

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    A convenient enantioselective CBS-reduction of arylketones in flow-microreactor systems

    S. De Angelis, M. De Renzo, C. Carlucci, L. Degennaro and R. Luisi, Org. Biomol. Chem., 2016, 14, 4304
    DOI: 10.1039/C6OB00336B

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