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Issue 24, 2016
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Synthesis of polymers and nanoparticles bearing polystyrene sulfonate brushes for chemokine binding

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Abstract

The movement of leukocytes to the site of inflammation in response to injury or infection is orchestrated by chemokines binding and signaling through cognate receptors. The interaction between sulfated tyrosine residues on the flexible N-terminal tail of the receptor with positively charged regions of the chemokine is one of the key recognition features that facilitates binding. In this manuscript we describe the synthesis of polymers and silica nanoparticles bearing polystyrene sulfonate brushes to mimic the sulfated tyrosine residues. We show that both the polymers and nanoparticles possess high binding affinity for the chemokine monocyte chemoattractant protein-1 (MCP-1) in monomeric and dimeric form. We also demonstrate key differences in the relative affinity for the chemokine for the free polymer versus the polymer-derived nanoparticle system.

Graphical abstract: Synthesis of polymers and nanoparticles bearing polystyrene sulfonate brushes for chemokine binding

  • This article is part of the themed collection: New Talent
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Article information


Submitted
01 Feb 2016
Accepted
22 Mar 2016
First published
23 Mar 2016

Org. Biomol. Chem., 2016,14, 5652-5658
Article type
Paper

Synthesis of polymers and nanoparticles bearing polystyrene sulfonate brushes for chemokine binding

N. Isahak, J. Sanchez, S. Perrier, M. J. Stone and R. J. Payne, Org. Biomol. Chem., 2016, 14, 5652
DOI: 10.1039/C6OB00270F

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