Issue 24, 2016

Selective chemical labeling of proteins


Over the years, there have been remarkable efforts in the development of selective protein labeling strategies. In this review, we deliver a comprehensive overview of the currently available bioorthogonal and chemoselective reactions. The ability to introduce bioorthogonal handles to proteins is essential to carry out bioorthogonal reactions for protein labeling in living systems. We therefore summarize the techniques that allow for site-specific “installation” of bioorthogonal handles into proteins. We also highlight the biological applications that have been achieved by selective chemical labeling of proteins.

Graphical abstract: Selective chemical labeling of proteins

  • This article is part of the themed collection: New Talent

Article information

Article type
Review Article
15 Jan 2016
23 Feb 2016
First published
23 Feb 2016
This article is Open Access
Creative Commons BY license

Org. Biomol. Chem., 2016,14, 5417-5439

Selective chemical labeling of proteins

X. Chen and Y. Wu, Org. Biomol. Chem., 2016, 14, 5417 DOI: 10.1039/C6OB00126B

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