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Issue 24, 2016
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Synthesis of 2-diphospho-myo-inositol 1,3,4,5,6-pentakisphosphate and a photocaged analogue

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Abstract

Diphosphoinositol polyphosphates (inositol pyrophosphates, X-InsP7) are a family of second messengers with important roles in eukaryotic biology. Their chemical synthesis and modification remains a challenging task due to the high density of phosphate groups arranged around the myo-inositol core. Here, a novel approach is presented that facilitates the incorporation of the diphosphate in the 2-position (2-InsP7) and that enables the introduction of a photocage subunit.

Graphical abstract: Synthesis of 2-diphospho-myo-inositol 1,3,4,5,6-pentakisphosphate and a photocaged analogue

  • This article is part of the themed collection: New Talent
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Publication details

The article was received on 13 Jan 2016, accepted on 24 Feb 2016 and first published on 24 Feb 2016


Article type: Communication
DOI: 10.1039/C6OB00094K
Org. Biomol. Chem., 2016,14, 5559-5562

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    Synthesis of 2-diphospho-myo-inositol 1,3,4,5,6-pentakisphosphate and a photocaged analogue

    I. Pavlovic, D. T. Thakor and H. J. Jessen, Org. Biomol. Chem., 2016, 14, 5559
    DOI: 10.1039/C6OB00094K

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