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Issue 15, 2016
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Synthesis of highly functionalized oligobenzamide proteomimetic foldamers by late stage introduction of sensitive groups

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Abstract

α-Helix proteomimetics represent an emerging class of ligands that can be used to inhibit an array of helix mediated protein–protein interactions. Within this class of inhibitor, aromatic oligobenzamide foldamers have been widely and successfully used. This manuscript describes alternative syntheses of these compounds that can be used to access mimetics that are challenging to synthesize using previously described methodologies, permitting access to compounds functionalized with multiple sensitive side chains and accelerated library assembly through late stage derivatisation.

Graphical abstract: Synthesis of highly functionalized oligobenzamide proteomimetic foldamers by late stage introduction of sensitive groups

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Supplementary files

Article information


Submitted
12 Jan 2016
Accepted
14 Mar 2016
First published
14 Mar 2016

This article is Open Access

Org. Biomol. Chem., 2016,14, 3782-3786
Article type
Paper
Author version available

Synthesis of highly functionalized oligobenzamide proteomimetic foldamers by late stage introduction of sensitive groups

G. M. Burslem, H. F. Kyle, P. Prabhakaran, A. L. Breeze, T. A. Edwards, S. L. Warriner, A. Nelson and A. J. Wilson, Org. Biomol. Chem., 2016, 14, 3782
DOI: 10.1039/C6OB00078A

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