Issue 7, 2016

Detection of weak hydrogen bonding to fluoro and nitro groups in solution using H/D exchange

Abstract

Hydrogen/deuterium (H/D) exchange can be a sensitive technique for measuring the strength of hydrogen bonding to neutral organic nitro and fluoro groups. The slower rates of reaction in comparison to suitable controls suggest that hydrogen bonding is present, albeit rather weak.

Graphical abstract: Detection of weak hydrogen bonding to fluoro and nitro groups in solution using H/D exchange

Supplementary files

Article information

Article type
Paper
Submitted
16 Nov 2015
Accepted
11 Jan 2016
First published
19 Jan 2016

Org. Biomol. Chem., 2016,14, 2223-2227

Author version available

Detection of weak hydrogen bonding to fluoro and nitro groups in solution using H/D exchange

C. R. Shugrue, J. R. DeFrancisco, A. J. Metrano, B. D. Brink, R. S. Nomoto and B. R. Linton, Org. Biomol. Chem., 2016, 14, 2223 DOI: 10.1039/C5OB02360B

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