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Issue 2, 2016
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A protocol for amide bond formation with electron deficient amines and sterically hindered substrates

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Abstract

A protocol for amide coupling by in situ formation of acyl fluorides and reaction with amines at elevated temperature has been developed and found to be efficient for coupling of sterically hindered substrates and electron deficient amines where standard methods failed.

Graphical abstract: A protocol for amide bond formation with electron deficient amines and sterically hindered substrates

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Article information


Submitted
14 Oct 2015
Accepted
05 Nov 2015
First published
05 Nov 2015

This article is Open Access

Org. Biomol. Chem., 2016,14, 430-433
Article type
Communication
Author version available

A protocol for amide bond formation with electron deficient amines and sterically hindered substrates

M. E. Due-Hansen, S. K. Pandey, E. Christiansen, R. Andersen, S. V. F. Hansen and T. Ulven, Org. Biomol. Chem., 2016, 14, 430
DOI: 10.1039/C5OB02129D

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