Issue 27, 2016
From the journal:

Nanoscale

N-Heterocyclic molecule-capped gold nanoparticles as effective antibiotics against multi-drug resistant bacteria†

Yan Feng,‡ac   Wenwen Chen,‡bc   Yuexiao Jia,c   Yue Tian,c   Yuyun Zhao,c   Fei Long,c   Yukui Rui*a  and  Xingyu Jiang*c  

* Corresponding authors

a College of Resources and Environmental Sciences, China Agricultural University, 2 YuanMingYuan West Road, HaiDian District, Beijing 100193, China
E-mail: ruiyukui@163.com
Fax: +8610 8254 5631
Tel: +86 10 8254 5558

b Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen 518060, China

c Beijing Engineering Research Center for BioNanotechnology & CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for NanoScience and Technology, 11 Beiyitiao, ZhongGuanCun, Beijing 100190, China
E-mail: xingyujiang@nanoctr.cn

Abstract

We demonstrate that N-heterocyclic molecule-capped gold nanoparticles (Au NPs) have broad-spectrum antibacterial activity. Optimized antibacterial activity can be achieved by using different initial molar ratios (1 : 1 and 10 : 1) of N-heterocyclic prodrugs and the precursor of Au NPs (HAuCl4). This work opens up new avenues for antibiotics based on Au NPs.

Graphical abstract: N-Heterocyclic molecule-capped gold nanoparticles as effective antibiotics against multi-drug resistant bacteria

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Article information

DOI
https://doi.org/10.1039/C6NR03317B
Article type
Communication
Submitted
25 Apr 2016
Accepted
14 Jun 2016
First published
15 Jun 2016

Nanoscale, 2016,8, 13223-13227

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N-Heterocyclic molecule-capped gold nanoparticles as effective antibiotics against multi-drug resistant bacteria

Y. Feng, W. Chen, Y. Jia, Y. Tian, Y. Zhao, F. Long, Y. Rui and X. Jiang, Nanoscale, 2016, 8, 13223 DOI: 10.1039/C6NR03317B

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