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Issue 7, 2016
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Hyperbranched polymer mediated size-controlled synthesis of gadolinium phosphate nanoparticles: colloidal properties and particle size-dependence on MRI relaxivity

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Abstract

Hyperbranched polymers based on the poly(amidoamine), HyPAM, were used to synthesize gadolinium phosphate nanowires under mild conditions. Control of the average particle size was obtained by adjusting polymer concentration. Proton relaxivity measurements reveal an optimum particle size, reaching relaxivity values as high as 55 ± 9 mM−1 s−1 for r1 and 67 ± 11 mM−1 s−1 for r2. The colloidal stability of these hybrid systems were optimized through the use of functionalized core–shell polymers containing PEG segments and C18-PEG segments, structures which also offer the possibility of imparting additional function into the polymer-particle hybrids.

Graphical abstract: Hyperbranched polymer mediated size-controlled synthesis of gadolinium phosphate nanoparticles: colloidal properties and particle size-dependence on MRI relaxivity

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Supplementary files

Article information


Submitted
28 Jul 2015
Accepted
25 Jan 2016
First published
26 Jan 2016

Nanoscale, 2016,8, 4252-4259
Article type
Paper
Author version available

Hyperbranched polymer mediated size-controlled synthesis of gadolinium phosphate nanoparticles: colloidal properties and particle size-dependence on MRI relaxivity

C. Frangville, M. Gallois, Y. Li, H. H. Nguyen, N. Lauth-de Viguerie, D. R. Talham, C. Mingotaud and J. Marty, Nanoscale, 2016, 8, 4252
DOI: 10.1039/C5NR05064B

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