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Issue 7, 2016
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DNA structure-specific sensitization of a metalloporphyrin leads to an efficient in vitro quadruplex detection molecular tool

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Abstract

The search for convenient molecular probes for detecting DNA and RNA quadruplexes in vitro is marked by a rapid pace of progress, spurred on by the multiple roles these higher-order nucleic acid structures play in many genetic dysregulations. Here, we contribute to this search, reporting on a palladated porphyrin named Pd·TEGPy: its efficiency as quadruplex-selective fluorescent dye relies on a structural design that endows it with attractive supramolecular and electronic properties and makes it an efficient turn-on, quadruplex-selective fluorescent stain thanks to a DNA-mediated sensitization mechanism that ensures a high level of specificity.

Graphical abstract: DNA structure-specific sensitization of a metalloporphyrin leads to an efficient in vitro quadruplex detection molecular tool

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Supplementary files

Article information


Submitted
31 Mar 2016
Accepted
09 May 2016
First published
10 May 2016

New J. Chem., 2016,40, 5683-5689
Article type
Paper

DNA structure-specific sensitization of a metalloporphyrin leads to an efficient in vitro quadruplex detection molecular tool

P. D. Diabate, A. Laguerre, M. Pirrotta, N. Desbois, J. Boudon, C. P. Gros and D. Monchaud, New J. Chem., 2016, 40, 5683
DOI: 10.1039/C6NJ01012A

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